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168 medications are known to interact with Antabuse. Includes atorvastatin, omeprazole, sertraline. Reviews and ratings for disulfiram. 94 reviews submitted with a 8.6 average score. Disulfiram blocks an enzyme that is involved in metabolizing alcohol intake. Disulfiram produces very unpleasant side effects when combined with alcohol in the  The anti-alcoholism drug disulfiram (Antabuse), which is an inhibitor of aldehyde dehydrogenase, induces an aversive reaction to alcohol consumption and 

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